Gene

rit1

ID

ZDB-GENE-070912-329

Name

Ras-like without CAAX 1

Symbol

rit1 Nomenclature History

Previous Names

si:ch211-93a2.3

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have GTPase activity; calmodulin binding activity; and purine ribonucleoside binding activity. Involved in embryonic viscerocranium morphogenesis and heart development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 8. Orthologous to several human genes including RIT1 (Ras like without CAAX 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rit1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Noonan syndrome 8	Alliance	Noonan syndrome 8	615355

Associated With rit1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR020849	Small GTPase, Ras-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase